Volume 24, No 2, Feb 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 2, February 2014: 141-142
RESEARCH HIGHLIGHTS
Regenerative medicine: Transdifferentiation in vivo
Lina Fu1,*, Xiping Zhu1,*, Fei Yi2,*, Guang-Hui Liu1,3 and Juan Carlos Izpisua Belmonte2,4
1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
3Beijing Institute for Brain Disorders, Beijing 100069, China
4Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, Barcelona 08003, Spain
Correspondence: Guang-Hui Liu, E-mail: ghliu@ibp.ac.cn; Juan Carlos Izpisua Belmonte, E-mail: belmonte@salk.edu(izpisua@cmrb.eu)
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.
10.1038/cr.2013.165
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