Volume 24, No 3, Mar 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 3, March 2014: 259-260

RESEARCH HIGHLIGHTS

Aberrant ceRNA activity drives lung cancer

Yvonne Tay¹, Florian A Karreth¹ and Pier Paolo Pandolfi¹

¹Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA Correspondence: Pier Paolo Pandolfi, Tel: +1-617-735-2121; Fax: +1-617-735-2120(ppandolf@bidmc.harvard.edu)

In a recent issue of Nature, Kumar et al. demonstrate that the oncogenic potential of the Hmga2 gene is largely due to the ability of its transcript to operate as a competing endogenous RNA in a protein coding-independent manner. The Hmga2 mRNA decoys the let-7 microRNA family to regulate Tgfbr3 expression and enhance TGF-β signaling, thereby promoting lung cancer progression.

10.1038/cr.2014.21

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