Volume 24, No 3, Mar 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 3, March 2014: 261-262
RESEARCH HIGHLIGHTS
Histone glutamine methylation afFACTing rDNA transcription
Heinrich Leonhardt1 and Sandra B Hake2
1Department of Biology II, Humanbiology and Bioimaging, Center for Integrated Protein Science (CIPSM), Ludwig Maximilians University Munich, 82152 Planegg-Martinsried, Germany
2Molecular Biology Unit, Adolf-Butenandt-Institute, Center for Integrated Protein Science Munich (CIPSM), Ludwig Maximilians University Munich, 80336 Munich, Germany
Correspondence: Heinrich Leonhardt, Tel: +49 89 2180 74232; Fax: +49 89 2180 74236 E-mail: h.leonhardt@lmu.de; Sandra B Hake, Tel: +49 89 2180 75435; Fax: +49 89 2180 75425(sandra.hake@med.uni-muenchen.de)
Chemical modifications of histone proteins directly and indirectly affect chromatin structure and thereby contribute to the multilayered control of diverse DNA-based processes. A recent study in Nature enriches this list of enzyme-dependent posttranslational histone marks by H2A glutamine methylation that appears to be dedicated to only one specific cellular process, the regulation of nucleolar rDNA transcription.
10.1038/cr.2014.22
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