Volume 24, No 3, Mar 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 3, March 2014: 263-264

RESEARCH HIGHLIGHTS

Where long noncoding RNAs meet DNA methylation

Fan Lai¹ and Ramin Shiekhattar¹

¹Wistar Institute, Philadelphia, PA 19104, USA Correspondence: Ramin Shiekhattar(Shiekhattar@wistar.org)

DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site through the association of ecCEBPA with DNA methyltransferase 1, DNMT1.

10.1038/cr.2014.13

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