Volume 24, No 4, Apr 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 4, April 2014: 383-384

RESEARCH HIGHLIGHT

Bone's dark side: mutated osteoblasts implicated in leukemia

Amir Schajnovitz^1,2,3 and David T Scadden^1,2,3

¹Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
²Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
³Harvard Stem Cell Institute, Cambridge, MA 02138, USA Correspondence: David T Scadden,(david_scadden@harvard.edu)

Bone lining osteolineage cells were previously implicated as contributors to hematological disorders and malignancies. A recent report in Nature now demonstrates that a specific mutation in mouse collagen-expressing osteoblastic cells leads to MDS and AML with 100% penetrance and is associated with strikingly similar findings in human patients.

10.1038/cr.2014.26

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