Volume 24, No 4, Apr 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 4, April 2014: 385-386

RESEARCH HIGHLIGHT

Unraveling hepatitis C virus structure

Catherine Fauvelle^1,2, Daniel J Felmlee^1,2 and Thomas F Baumert^1,2,3

¹Inserm Unit 1110, Université de Strasbourg, 3 rue Koeberlé, F-67000 Strasbourg, France
²Pôle Hépato-digestif, Université de Strasbourg, Strasbourg, France
³Hôpitaux Universitaires de Strasbourg, Strasbourg, France Correspondence: Thomas F Baumert, Tel: (33) 3 68 85 37 03; Fax: (33) 3 68 85 37 50(Thomas.Baumert@unistra.fr)

The high variability and the limited knowledge of the structure of the hepatitis C virus (HCV) envelope glycoproteins (GP) are challenging hurdles for vaccine design. Recently, Kong et al. published a new model of HCV E2 GP structure in Science, revealing a globular structure, starkly contrasting from the extended model of class II fusion proteins from other Flaviviridae viruses.

10.1038/cr.2014.31

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