Volume 24, No 4, Apr 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 4, April 2014: 505-508

LETTERS TO THE EDITOR

Recurrent mutations at C-reactive protein gene promoter SNP position −286 in human cancers

Ming-Yu Wang^1,*, Hai-Hong Zhou^1,*, Shi-Chao Zhang^1,*, Feng Hui^1,*, Wei Zhu², Hai-Xiang Su³, Hong-Yun Guo³, Xing-Wen Li³, Shang-Rong Ji¹ and Yi Wu^1,4

¹MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China
²The Second Hospital, Lanzhou University, Lanzhou, Gansu 730000, China
³The Gansu Cancer Hospital, Lanzhou 730050, China
⁴Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, Gansu 730000, China Correspondence: Yi Wu, Tel/Fax: +86-931-8914102 E-mail: wuy@lzu.edu.cn; Shang-Rong Ji, Tel/Fax: +86-931-8914176(jsr@lzu.edu.cn)

Genetic alteration and inflammation underlie the development of cancer1. C-reactive protein (CRP) is the most widely used nonspecific marker of inflammation2, whose serum level has been shown to be associated with the risk and prognosis of several types of cancer3. Accumulating evidence supports a role of CRP as a pattern recognition receptor in the innate immunity and inflammation4; however, its exact function remains to be defined because mouse is not an appropriate animal model for CRP5.

10.1038/cr.2014.7

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