Volume 24, No 4, Apr 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 4, April 2014: 387-388

RESEARCH HIGHLIGHT

Mitofusins: ubiquitylation promotes fusion

Mafalda Escobar-Henriques¹

¹Institute for Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany Correspondence: Mafalda Escobar-Henriques, E-mail: Mafalda.Escobar@uni-koeln.de

Mitochondrial genes including Mfn2 are at the center of many diseases, underscoring their potential as a therapeutical target. The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30, acting on Mfn1 and Mfn2.

10.1038/cr.2014.23

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