Volume 24, No 6, Jun 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 6, June 2014: 641-642
RESEARCH HIGHLIGHTS
A chemical approach to “rewire” neural progenitor cells
Min-Zu Wu1, Mo Li1, Guang-Hui Liu2,3 and Juan Carlos Izpisua Belmonte1
1Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA
2National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
3Beijing Institute for Brain Disorders, Beijing 100875, China
Correspondence: Juan Carlos Izpisua Belmonte,(belmonte@salk.edu)
Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.
10.1038/cr.2014.51
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