Volume 24, No 6, Jun 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 6, June 2014: 643-644
RESEARCH HIGHLIGHTS
'Lnc'-ing enhancers to MYC regulation
Scott T Younger1,2 and John L Rinn1,2,3
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Correspondence: John L Rinn,(johnrinn@fas.harvard.edu)
Long noncoding RNAs (lncRNAs) are emerging as important functional components in the establishment of long-range chromosomal interactions. In a recent paper published in Cell Research, Xiang et al. provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L, a colorectal cancer-specific lncRNA, in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.
10.1038/cr.2014.54
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