Volume 24, No 6, Jun 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 6, June 2014: 645-646

RESEARCH HIGHLIGHTS

The lock-washer: a reconciliation of the RIG-I activation models

Shu Zhu^1,*, Ruaidhri Jackson^1,* and Richard A Flavell^1,2

¹Department of Immunobiology, Yale University New Haven, CT 06520, USA
²Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA Correspondence: Richard A Flavell,(richard.flavell@yale.edu)

RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-linked ubiquitin chains, uncovering its activation mechanism for downstream signaling.

10.1038/cr.2014.58

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