Volume 24, No 6, Jun 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 6, June 2014: 649-650

RESEARCH HIGHLIGHTS

Recognizing methylated histone variant H3.3 to prevent tumors

Swaminathan Venkatesh¹ and Jerry L Workman¹

¹Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA Correspondence: Jerry L Workman,(jlw@stowers.org)

Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors.

10.1038/cr.2014.50

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