Volume 24, No 7, Jul 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 7, July 2014: 783-784
RESEARCH HIGHLIGHTS
Identifying specific receptors for cargo-mediated autophagy
Megan Goodall1 and Andrew Thorburn1
1Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Correspondence: Andrew Thorburn,(Andrew.Thorburn@ucdenver.edu)
Macroautophagy has been implicated in numerous diseases, yet our understanding of the proteins responsible for the turnover of specific cargo by autophagy is limited. In a recent paper published in Nature, Mancias et al. used quantitative proteomics to identify a cohort of autophagosome-enriched proteins, one of which, nuclear receptor coactivator 4 (NCOA4) was shown to be required for the selective delivery of ferritin to the lysosome, ultimately regulating intracellular iron by autophagic turnover of ferritin, or ferritinophagy.
10.1038/cr.2014.56
FULL TEXT | PDF
Browse 1770
