Volume 24, No 7, Jul 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 7, July 2014: 777-778

RESEARCH HIGHLIGHTS

Notching up vascular regeneration

Bing Zhang¹ and William T Pu^1,2

¹Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA
²Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA Correspondence: (E-mail: wpu@pulab.org)

Regenerative medicine for cardiovascular disease requires effective approaches for therapeutic revascularization. In a recent paper in Cell Research, Sahara et al. establish a new role for Notch signaling to promote endothelial progenitor differentiation, and develop a protocol based on Notch inhibition in endothelial progenitors to markedly enhance the yield and purity of functional endothelial cells differentiated from embryonic stem cells.

10.1038/cr.2014.68

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