Volume 24, No 7, Jul 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 7, July 2014: 785-786
RESEARCH HIGHLIGHTS
Akt: a new activation mechanism
Yuan Gao1,2, Asad Moten1,5 and Hui-Kuan Lin1,2,3,4
1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
3Graduate Institute of Basic Medical Science, China Medical University, Taichung 404
4Department of Biotechnology, Asia University, Taichung 404
5Department of Primary Care Health Sciences, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, UK
Correspondence: Hui-Kuan Lin,(hklin@mdanderson.org)
Akt phosphorylation at S473 and T308 has been believed to be the prerequisites for its activation for years. Now, new phosphorylation event on Akt is identified and can trigger Akt activation and lead to its downstream oncogenic events.
10.1038/cr.2014.57
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