Volume 24, No 9, Sep 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 9, September 2014: 1023-1024

RESEARCH HIGHLIGHTS

Driving glioblastoma growth by alternative polyadenylation

Ting Han¹ and John K Kim²

¹Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390-9152, USA
²Life Sciences Institute, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA Correspondence: John K Kim,(jnkim@umich.edu)

Global shortening of 3′ untranslated regions (3′ UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3′ UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.

10.1038/cr.2014.88

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