Volume 24, No 9, Sep 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 9, September 2014: 1025-1026

RESEARCH HIGHLIGHTS

Phosphorylated ubiquitin: a new shade of PINK1 in Parkin activation

Véronique Sauvé¹ and Kalle Gehring¹

¹Department of Biochemistry and GRASP, McGill University, Montréal QC H3G 0B1, Canada Correspondence: Kalle Gehring,(kalle.gehring@mcgill.ca)

The Parkinson's disease (PD)-associated proteins, Parkin and PINK1, together comprise a mitochondrial quality control pathway that promotes neuronal survival through autophagy of damaged mitochondria. Three recent studies have found that Parkin recruitment to mitochondria and ubiquitin ligase activity is controlled by the phosphorylation of ubiquitin by PINK1.

10.1038/cr.2014.79

FULL TEXT | PDF

Browse 1905