Volume 24, No 9, Sep 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 9, September 2014: 1027-1028
RESEARCH HIGHLIGHTS
“PEST control”: regulation of molecular barcodes by tyrosine phosphatases
Karen M Doody1 and Nunzio Bottini1
1Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Correspondence: Nunzio Bottini, Tel: +1-858-752-6815(nunzio@lji.org)
The emerging concept of “molecular barcodes” refers to the dynamic combination of post-translational modifications, often of different nature (e.g., phosphorylation and ubiquitination) that gives rise to multiple forms of a protein which can relay distinct signals throughout a cell. In a recent Cell Research paper by Wang et al., the authors report that a PEST domain-containing tyrosine phosphatase, PTPN18, is able to regulate both phosphorylation and ubiquitination of the HER2 oncogene, barcoding HER2 for increased proteasomal degradation rather than for intracellular trafficking.
10.1038/cr.2014.100
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