Volume 24, No 9, Sep 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 9, September 2014: 1029-1030

RESEARCH HIGHLIGHTS

Autophagy regulation: RNF2 targets AMBRA1

Etienne Morel¹, Nicolas Dupont¹ and Patrice Codogno¹

¹INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM) Université, Paris Descartes-Sorbonne Paris Cité Paris, 75993 Paris, cedex 14, France Correspondence: Etienne Morel, E-mail: etienne.morel@inserm.fr; Patrice Codogno,(patrice.codogno@inserm.fr)

The phosphatidylinositol 3-kinase complex I (PI3K complex I) is a crucial regulator of autophagy, which contains Beclin 1 (or ATG6), ATG14L, VPS34 (or the class III phosphatidylinositol 3-kinase and its adaptor VPS15) and AMBRA1, and controls autophagosome formation. In a paper recently published in Cell Research, Xia et al. report that during nutrient deprivation the ubiquitin E3 ligase RNF2 is recruited to the PI3K complex I, and ubiquitinates AMBRA1 to trigger its degradation and downregulate autophagy.

10.1038/cr.2014.105

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