Volume 24, No 9, Sep 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 9, September 2014: 1031-1032
RESEARCH HIGHLIGHTS
Rbpj links uterine transformation and embryo orientation
Joshua F Robinson1,2,3 and Susan J Fisher1,2,3,4,5,6
1Center for Reproductive Sciences, San Francisco, CA 94143, USA
2Department of Obstetrics, Gynecology, and Reproductive Sciences, San Francisco, CA 94143, USA
3The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA
4Division of Maternal Fetal Medicine, San Francisco, CA 94143, USA
5Department of Anatomy, San Francisco, CA 94143, USA
6Human Embryonic Stem Cell Program, UCSF, San Francisco, CA 94143, USA
Correspondence: Susan J Fisher,(sfisher@cgl.ucsf.edu)
Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine closure and proper embryo alignment during implantation in the mouse, raising the possibility that aberrant Rbpj signaling could contribute to infertility in humans.
10.1038/cr.2014.110
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