Volume 24, No 10, Oct 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 10, October 2014: 1157-1158

RESEARCH HIGHLIGHTS

UV and melanoma: mechanistic contributions, complexities and opportunities

Yeon Sook Choi¹ and David E Fisher¹

¹Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA Correspondence: David E Fisher,(dfisher3@partners.org)

Ultraviolet radiation (UVR) is a major risk factor for melanoma development, but it has been unclear exactly how UVR leads to melanomagenesis. In a recent publication in Nature, Viros et al. identify TP53/Trp53 as a UVR-target gene in melanoma and show that UVR-induced TP53/Trp53 mutations accelerate BRAF(V600E)-driven melanomagenesis.

10.1038/cr.2014.95

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