Volume 24, No 10, Oct 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 10, October 2014: 1162-1163

RESEARCH HIGHLIGHTS

Where cell fate conversions meet Chinese philosophy

Hui Zheng¹, Andrew Paul Hutchins¹, Guangjin Pan¹, Yinxiong Li¹, Duanqing Pei¹ and Gang Pei²

¹Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China
²Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Shanghai 200031, China Correspondence: Duanqing Pei, E-mail: pei_duanqing@gibh.ac.cn; Gang Pei,(gpei@sibs.ac.cn)

Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian cells fall into two grand divisions, mesenchymal or epithelial; interconversions between these two grand divisions through EMT/MET resonate with some ancient Chinese philosophic ideas.

10.1038/cr.2014.93

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