Volume 24, No 10, Oct 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 10, October 2014: 1270-1273
LETTERS TO THE EDITOR
Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP
Zhenhua Ming1,*, Wei Wang1,4,*, Yuchen Xie1, Pengfei Ding5, Yuchao Chen1,4, Dazhi Jin6, Yuna Sun3, Bin Xia5, Liming Yan2 and Zhiyong Lou1,7
1Structural Biology Laboratory and MOE laboratory of Protein Science, School of Medicine and Life Science, Tsinghua University, Beijing 100084, China
2Tsinghua-Peking Center for Life Sciences, Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, 100084, China
3National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China
4Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China
5Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, and School of Life Sciences, Peking University, Beijing 100871, China
6Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang 310051, China
7Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610207 China
Correspondence: Zhiyong Lou, E-mail: louzy@xtal.tsinghua.edu.cn; Liming Yan,(yanlm@xtal.tsinghua.edu.cn)
Through production of cyclic di-nucleotides as second messengers, di-nucleotide cyclases in bacteria and more recently in mammalian cells have been found to play important roles in modulating a wide range of cellular processes1. During infection of Vibrio cholerae (V. cholerae), di-nucleotide cyclase Vibrio (DncV) is required for efficient intestinal colonization by V. cholerae and downregulates hyperinfectivity-associated V. cholerae chemotaxis through generation of a regulatory molecule cyclic GMP-AMP (cGAMP)2.
10.1038/cr.2014.123
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