Volume 24, No 11, Nov 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 11, November 2014: 1280-1281

RESEARCH HIGHLIGHTS

Entosis, a key player in cancer cell competition

Guido Kroemer^1,2,3,4 and Jean-Luc Perfettini^5,6,7,8

¹Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, F-75006 Paris, France
²Université Paris Descartes, Sorbonne Paris Cité, F-75005 Paris, France
³Metabolomics and Cell Biology Platforms, Gustave Roussy, F-94805 Villejuif, France
⁴Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75015 Paris, France
⁵Cell death and Aging team, Gustave Roussy, F-94805 Villejuif, France
⁶Laboratory of Molecular Radiotherapy, INSERM U1030, Gustave Roussy, F-94805 Villejuif, France
⁷Gustave Roussy, F-94805 Villejuif, France
⁸Université Paris Sud - Paris 11, F-94805 Villejuif, France Correspondence: Guido Kroemer,(kroemer@orange.fr)

Cell-in-cell structures, also referred to as 'entosis', are frequently found in human malignancies, although their prognostic impact remains to be defined. Two articles recently published in Cell Research report the stimulation of entosis by one prominent oncogene, Kras, as well as by one class of tumor suppressors, namely epithelial cadherins E and P, illustrating the complex regulation of this biological process.

10.1038/cr.2014.133

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