Volume 24, No 11, Nov 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 11, November 2014: 1282-1283

RESEARCH HIGHLIGHTS

Cancer signaling: when phosphorylation meets methylation

Haoqiang Ying¹ and Ronald A DePinho²

¹Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
²Departments of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Correspondence: Ronald A DePinho,(rdepinho@mdanderson.org)

The propagation of kinase-mediated phosphorylation signals is central to the oncogenic activity of the RAS-MAPK pathway in human cancers. A recent study shows that protein lysine methylation controls the phosphorylation status of a key component of the RAS-MAPK pathway to enable oncogenic KRAS in cancer progression.

10.1038/cr.2014.103

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