Volume 24, No 11, Nov 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 11, November 2014: 1286-1287

RESEARCH HIGHLIGHTS

Detecting “different”: Pyrin senses modified GTPases

Marcel R de Zoete^1,2 and Richard A Flavell^1,2

¹Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
²Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA Correspondence: Richard A Flavell,(richard.flavell@yale.edu)

Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process.

10.1038/cr.2014.101

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