Volume 24, No 12, Dec 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 12, December 2014: 1383-1384

RESEARCH HIGHLIGHTS

Mixed messages: Re-initiation factors regulate translation of animal mRNAs

Benedikt Obermayer¹ and Nikolaus Rajewsky¹

¹Max Delbrück Center (MDC) for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin-Buch, Germany Correspondence: Nikolaus Rajewsky,(rajewsky@mdc-berlin.de)

When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5′ untranslated region (5′ UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.

10.1038/cr.2014.114

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