Volume 24, No 12, Dec 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 12, December 2014: 1385-1386

RESEARCH HIGHLIGHTS

Backseat drivers: Cargo adaptors and dynactin activate cytoplasmic dynein motility

Mark P Dodding¹

¹Randall Division of Cell and Molecular Biophysics, King's College London, SE1 1UL, UK Correspondence: Mark P Dodding,(mark.dodding@kcl.ac.uk)

Control of the activity of the microtubule motor cytoplasmic dynein 1 is essential for its function in intracellular transport. A recent paper by McKenney et al. published in Science shows that activation of processive dynein motility requires the formation of cargo adaptor-dynein-dynactin complexes.

10.1038/cr.2014.115

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