Volume 25, No 1, Jan 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 1, January 2015: 3-4

RESEARCH HIGHLIGHTS

FTO: linking m⁶A demethylation to adipogenesis

Moshe Shay Ben-Haim^1,2, Sharon Moshitch-Moshkovitz¹ and Gideon Rechavi^1,2

¹Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
²Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel Correspondence: Gideon Rechavi,(Gidi.Rechavi@sheba.health.gov.il)

Polymorphism of the FTO gene encoding an N⁶-methyladenosine (m⁶A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

10.1038/cr.2014.162

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