Volume 25, No 2, Feb 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 2, February 2015: 149-150

RESEARCH HIGHLIGHTS

WildCARDs: Inflammatory caspases directly detect LPS

Jon Alan Hagar¹, Youssef Aachoui¹ and Edward Axel Miao¹

¹Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Correspondence: Edward Axel Miao,(emiao@med.unc.edu)

Inflammasomes are sensors that serve as activation platforms for caspase-1 — a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.

10.1038/cr.2014.128

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