Volume 25, No 3, Mar 2015
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 25 Issue 3, March 2015: 273-274
RESEARCH HIGHLIGHTS
DUBA-UBR5 axis: other than transactivation
Chuan Wu1, Zuojia Chen1 and Vijay K Kuchroo1
1Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA
Correspondence: Vijay K Kuchroo,(vkuchroo@rics.bwh.harvard.edu)
The genomic and transcriptomic analysis has led to the identification of transcriptional networks that affect the differentiation of Th17 cells, while the protein-protein networks and the posttranslational modifications that control the development of Th17 cells have not been established yet. A recent publication by Rutz et al. in Nature describes a novel deubiquitylating enzyme DUBA as a negative regulator for IL-17 by regulating stability of RORγt, the master transcription factor that induces Th17 cells.
10.1038/cr.2015.13
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