Volume 25, No 7, Jul 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 7, July 2015: 767-768

RESEARCH HIGHLIGHTS

Targeted genome editing in primate embryos

Xiangyu Guo¹ and Xiao-Jiang Li^1,2

¹Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
²Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA Correspondence: Xiao-Jiang Li,(xli2@emory.edu)

Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases.

10.1038/cr.2015.64

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