Volume 25, No 7, Jul 2015
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 25 Issue 7, July 2015: 767-768
RESEARCH HIGHLIGHTS
Targeted genome editing in primate embryos
Xiangyu Guo1 and Xiao-Jiang Li1,2
1Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Correspondence: Xiao-Jiang Li,(xli2@emory.edu)
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases.
10.1038/cr.2015.64
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