Volume 25, No 7, Jul 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 7, July 2015: 885-886

RESEARCH HIGHLIGHT

Sodium-activated macrophages: the salt mine expands

Liliana E Lucca¹ and David A Hafler¹

¹Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA Correspondence: David Hafler,(david.hafler@yale.edu)

High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases. Now Zhang and colleagues show that high sodium drives macrophage to acquire a new proinflammatory effector phenotype with a distinct signature, paving the path to assess the role of salt-activated macrophages in human disease.

10.1038/cr.2015.91

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