Volume 25, No 9, Sep 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 9, September 2015: 995-996

RESEARCH HIGHLIGHTS

DNA damage and repair regulate neuronal gene expression

Yijing Su^1,2, Guo-li Ming^1,2,3,4 and Hongjun Song^1,2,3

¹Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
²Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
³The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
⁴Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Correspondence: Hongjun Song,(shongju1@jhmi.edu)

Neuronal activity-induced gene expression is crucial for the development and plasticity of the brain and for learning and memory. In a recent study published in Cell, Madabhushi et al. report that neuronal activity triggers the formation of DNA double-strand breaks on promoters of early response genes, which in turn controls their expression in neurons.

10.1038/cr.2015.85

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