Volume 25, No 9, Sep 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 9, September 2015: 1078-1081

LETTERS TO THE EDITOR

Structural basis of the Norrin-Frizzled 4 interaction

Guobo Shen^1,2,*, Jiyuan Ke^3,*, Zhizhi Wang¹, Zhihong Cheng¹, Xin Gu³, Yuquan Wei², Karsten Melcher³, H Eric Xu^3,4 and Wenqing Xu¹

¹Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
²State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China
³Van Andel Research Institute, Grand Rapids, MI 49503, USA
⁴VARI-SIMM Center, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Correspondence: Wenqing Xu, E-mail: wxu@uw.edu; H Eric Xu,(Eric.Xu@vai.org)

Norrin, also known as the Norrie disease protein or X-linked exudative vitreoretinopathy 2 protein, is a secreted retinal growth factor with angiogenic and neuroprotective properties. Mutations in the NPD gene, which encodes the Norrin protein, are associated with Norrie disease, familial exudative

10.1038/cr.2015.92

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