Volume 25, No 10, Oct 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 10, October 2015: 1085-1086

RESEARCH HIGHLIGHTS

mTORC1 maintains metabolic balance

Heesun Cheong¹ and Daniel J Klionsky²

¹Comparative Biomedicine Research Branch, Division of Cancer Biology, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do 410-769, Republic of Korea
²University of Michigan, Life Sciences Institute, Ann Arbor, MI 481098-2216, USA Correspondence: Heesun Cheong, E-mail: heesunch@ncc.re.kr; Daniel J Klionsky,(klionsky@umich.edu)

Anticancer therapeutics aimed at the inhibition of mTORC1 activity shift metabolism to favor the degradation of extracellular proteins. Recently Thompson and colleagues demonstrated a novel regulatory mechanism whereby mTORC1 plays a distinct role as a key regulator of metabolism depending on the environmental nutrient status.

10.1038/cr.2015.107

FULL TEXT | PDF

Browse 2129