Volume 25, No 10, Oct 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 10, October 2015: 1089-1090

RESEARCH HIGHLIGHTS

RNA Pol II as a sensor of 5caC

Jian-Huang Xue¹ and Guo-Liang Xu¹

¹Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Correspondence: Guo-Liang Xu,(glxu@sibs.ac.cn)

Cytosines in genomic DNA come in different flavors. A recent paper published in Nature reveals that an oxidized variety, 5-carboxylcytosine, is recognized by the elongating RNA polymerase, shedding light on the role of DNA oxidation in transcription regulation.

10.1038/cr.2015.103

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