Volume 25, No 10, Oct 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 10, October 2015: 1175-1178

LETTERS TO THE EDITOR

YAP activates the Hippo pathway in a negative feedback loop

Xiaoming Dai^1,*, Huan Liu^1,*, Shuying Shen^1,2, Xiaocan Guo¹, Huan Yan¹, Xinyan Ji¹, Li Li³, Jun Huang¹, Xin-Hua Feng¹ and Bin Zhao¹

¹Life Sciences Institute and Innovation Center for Cell Signaling Network, Hangzhou, Zhejiang 310058, China
²Institute of Biochemistry, College of Life Science, Hangzhou, Zhejiang 310058, China
³Institute of Aging Research, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China Correspondence: binzhao@zju.edu.cn

A relatively constant organ size is one of the most striking yet mysterious features of multicellular organisms, which was recently found to be regulated by the Hippo pathway in an evolutionarily conserved manner. Inactivation of this pathway leads to drastic enlargement of organ size due to a marked increase of cell number1. Furthermore, deregulation of the Hippo pathway plays broad roles in human cancer development from tumorigenesis to cancer relapse2.

10.1038/cr.2015.101

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