Volume 25, No 11, Nov 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 11, November 2015: 1181-1182

RESEARCH HIGHLIGHTS

Probing hepatocyte heterogeneity

Ben Z Stanger¹

¹Departments of Medicine and Cell and Developmental Biology, BRB II/III, Rm. 512, 421 Curie Boulevard, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 Correspondence:

To maintain homeostasis, organs replace cells lost through normal cellular turnover, often through the straightforward replication of existing cells. A recent paper in Nature shows that cells in the liver are not equivalent when it comes to their replicative capacity; rather, a subset of hepatocytes defined by the maintenance of active Wnt signaling bears the brunt of responsibility for maintaining liver mass.

10.1038/cr.2015.117

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