Volume 25, No 11, Nov 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 11, November 2015: 1183-1184

RESEARCH HIGHLIGHTS

Gasdermin D: the long-awaited executioner of pyroptosis

Si Ming Man¹ and Thirumala-Devi Kanneganti¹

¹Department of Immunology, St. Jude Children's Research Hospital, MS #351, 262 Danny Thomas Place, Memphis, TN 38105, USA Correspondence: Thirumala-Devi Kanneganti, Tel: +1-901-595-3634; Fax: +1-901-595-5766(Thirumala-Devi.Kanneganti@stjude.org)

Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

10.1038/cr.2015.124

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