Volume 25, No 11, Nov 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 11, November 2015: 1185-1186

RESEARCH HIGHLIGHTS

New tricks from an old dog: Another synaptotoxic fragment from APP

Sheue-Houy Tyan¹ and Edward H Koo^1,2

¹Department of Medicine, National University of Singapore, Singapore
²Department of Neurosciences, University of California San Diego, La Jolla, USA Correspondence: Edward H Koo, Tel: +1-858-822-1024; Fax: +1-858-822-1021(edkoo@ucsd.edu)

In a surprising twist, a hitherto unrecognized cleavage of the amyloid precursor protein (APP) by η-secretase, followed by α- or β-secretase cleavage releases a novel APP proteolytic fragment, Aη, which causes synaptic injury.

10.1038/cr.2015.125

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