Volume 25, No 12, Dec 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 12, December 2015: 1281-1282

RESEARCH HIGHLIGHTS

The quest for spatio-temporal control of CAR T cells

Jie Sun^1,2 and Michel Sadelain^1,2

¹Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
¹Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA Correspondence: Michel Sadelain,(m-sadelain@ski.mskcc.org)

Chimeric antigen receptors (CARs) are synthetic receptors capable of directing potent antigen-specific anti-tumor T cell responses. A recent report by Wu et al. extends a series of strategies aiming to curb excessive T cell activity, utilizing in this instance a chemical dimerizer to aggregate antigen-binding, T cell-activating and costimulatory domains.

10.1038/cr.2015.131

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