Volume 25, No 12, Dec 2015

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 25 Issue 12, December 2015: 1283-1284

RESEARCH HIGHLIGHTS

RNA editing by ADAR1 marks dsRNA as “self”

Zhou Yu¹, Taoyong Chen² and Xuetao Cao^1,2

¹National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
²National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China Correspondence: Xuetao Cao,(caoxt@immunol.org)

A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.

10.1038/cr.2015.135

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