Volume 26, No 1, Jan 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 1, January 2016: 1-2

RESEARCH HIGHLIGHTS

mTORC2 is a tyrosine kinase

Xuemin Wang¹ and Christopher G Proud¹

¹Nutrition and Metabolism Theme, South Australian Health & Medical Research Institute, North Terrace, and University of Adelaide, Adelaide, Australia Correspondence: Christopher G Proud,(Christopher.Proud@sahmri.com)

The mammalian target of rapamycin (mTOR), a protein kinase, is the centre of huge attention due to its importance in intracellular signaling and in health and disease. Nonetheless research in this area continues to generate surprise. In their recent study, Yin et al. show that mTOR can regulate signaling through the insulin-like growth factor 1 (IGF-1) receptor and that it possesses a new enzymatic activity — the ability to phosphorylate proteins on tyrosine residues.

10.1038/cr.2015.134

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