Volume 26, No 1, Jan 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 1, January 2016: 3-4
RESEARCH HIGHLIGHTS
Cancer immunosurveillance: role of patrolling monocytes
Luca Cassetta1 and Jeffrey W Pollard1,2
1MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK
2Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
Correspondence: Jeffrey W Pollard,(Jeff.Pollard@ed.ac.uk)
Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8+ T and NK cells restrict tumor growth. In a recent paper published in Science, Hanna and colleagues demonstrate that another monocyte population, nonclassical patrolling monocytes, is enriched in the microvasculature of tumor-challenged lung and reduces tumor metastasis by recruiting NK cells.
10.1038/cr.2015.144
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