Volume 26, No 1, Jan 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 1, January 2016: 7-20

REVIEWS

Multiple amino acid sensing inputs to mTORC1

Mitsugu Shimobayashi¹ and Michael N Hall¹

¹Biozentrum, University of Basel, Basel, Switzerland Correspondence: Michael N Hall,(m.hall@unibas.ch)

The evolutionarily conserved target of rapamycin complex 1 (TORC1) is a master regulator of cell growth and metabolism. In mammals, growth factors and cellular energy stimulate mTORC1 activity through inhibition of the TSC complex (TSC1-TSC2-TBC1D7), a negative regulator of mTORC1. Amino acids signal to mTORC1 independently of the TSC complex. Here, we review recently identified regulators that link amino acid sufficiency to mTORC1 activity and how mutations affecting these regulators cause human disease.

10.1038/cr.2015.146

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