Volume 26, No 2, Feb 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 2, February 2016: 147-148

RESEARCH HIGHLIGHTS

The XEN of reprogramming

Ergin Beyret¹ and Juan Carlos Izpisua Belmonte¹

¹Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA Correspondence: Juan Carlos Izpisua Belmonte, Tel: +1 (858) 453-4100 ext. 1130(belmonte@salk.edu)

Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer, cell fusion or genetic manipulation. Two recent papers from Hongkui Deng's group now show various cell types can be reprogrammed simply by chemicals through an extraembryonic endoderm-like phase instead of the primitive streak-like mesendoderm induced by Yamanaka factors.

10.1038/cr.2016.9

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