Volume 26, No 2, Feb 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 2, February 2016: 262-265

LETTERS TO THE EDITOR

Monocyte-derived Wnt5a regulates inflammatory lymphangiogenesis

Roberto Sessa^1,2, Don Yuen^1,2, Stephanie Wan^1,2, Michael Rosner^1,2, Preethi Padmanaban^1,2, Shaokui Ge², April Smith³, Russell Fletcher⁴, Ariane Baudhuin-Kessel⁴, Terry P Yamaguchi⁵, Richard A Lang³ and Lu Chen^1,2

¹Vision Science Graduate Group, University of California, Berkeley, CA, USA
²Center for Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, CA, USA
³Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
⁴Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
⁵Center for Cancer Research, National Institutes of Health, Frederick, MD, USA Correspondence: Lu Chen, Tel: +1-510-642-5076(chenlu@berkeley.edu)

Lymphatic research signifies a field of explosive discovery in recent years1,2,3. The lymphatic network penetrates most tissues in the body and its dysfunction has been found in a broad spectrum of disorders from inflammation to cancer metastasis and transplant rejection. However, to date, there are few effective treatments for lymphatic diseases. It is therefore important and urgent to investigate the fundamental mechanisms of pathological lymphangiogenesis (LG, the formation of new lymphatic vessels) for the development of new therapeutic strategies. The cornea offers an ideal site for pathological LG research due to its transparent nature and inducible LG3. Since there are no pre-existing or background vessels to consider, it is exceptionally straightforward and accurate to assess LG in response to a pathological insult, such as inflammation.

10.1038/cr.2015.105

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