Volume 26, No 3, Mar 2016
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 26 Issue 3, March 2016: 267-268
RESEARCH HIGHLIGHTS
Structural insights of mTOR complex 1
Hai-Xin Yuan1 and Kun-Liang Guan2
1Molecular Cell Biology Laboratory, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
2Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
Correspondence: Hai-Xin Yuan, E-mail: yuanhaixin@fudan.edu.cn; Kun-Liang Guan,(kuguan@ucsd.edu)
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights into the regulation and substrate selectivity of mTORC1.
10.1038/cr.2016.10
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