Volume 26, No 3, Mar 2016

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 26 Issue 3, March 2016: 271-272

RESEARCH HIGHLIGHTS

Lupus pathogenesis: role of IgE autoantibodies

Jagadeesh Bayry^1,2,3,4

¹Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris, F-75006, France
²Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, F-75006, France;
³Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris, F-75006, France;
⁴Centre de Recherche des Cordeliers, Equipe - Immunopathologie et immuno-intervention thérapeutique, Paris, F-75006, France Correspondence: Jagadeesh Bayry,(jagadeesh.bayry@crc.jussieu.fr)

IgE is commonly known for its role in the Th2 responses, protection against helminth parasites and pathogenesis of allergy. A recent report shows that IgE autoantibodies to dsDNA plays a major role in the pathogenesis of lupus nephritis by exacerbating the interferon-α responses in plasmacytoid dendritic cells.

10.1038/cr.2016.12

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